The 63-year-old former NHS chief nurse has been named as the new Archbishop of Canterbury designate - making history as the initial female to be chosen for this significant position.
Previously England's chief nursing officer, the 63-year-old became a priest in 2006 and was appointed as the first female Bishop of London in 2018 - the third most senior member of clergy in the Church of England.
This signifies the initial occasion in nearly 500 years of history that the Church has chosen a female to assume its leadership.
The Anglican Church has been lacking an individual in the leading position for approximately twelve months after Justin Welby stepped down over a safeguarding scandal.
He departed following a critical investigation into a prolific child abuser linked to the Church. The report found that he "was able and obligated" have notified authorities about the misconduct by John Smyth of male youths to law enforcement in 2013.
The Archbishop of York assumed most of the former Archbishop's responsibilities in an interim move, and was one of the voting members of the body tasked with selecting his replacement.
In line with tradition, the process of selecting a new archbishop involves a name being given to Prime Minister Sir Keir Starmer and then passed to the sovereign.
Sir Keir has applauded the selection of Dame Sarah, stating: "This position will serve an important function in our country's affairs. I offer my best wishes and anticipate collaborating."
Although formally, the monarch is head of the Church of England, the person holding the position of Archbishop of Canterbury is the highest-ranking cleric and is the spiritual leader of the religious institution and the worldwide Anglican Communion.
The monarch has congratulated Dame Sarah on her appointment, "a position of great significance in the United Kingdom and across the global Anglican Communion", Buckingham Palace stated.
The Global Fellowship of Confessing Anglicans, which advocates for traditional positions, has questioned the appointment, stating that although certain groups support the decision, "the majority of the Anglican Communion still maintains that the scriptures mandates a all-male bishopric."
She does not legally take on her position until a formal approval process in January, and an enthronement service comes subsequently, after they have paid homage to the King.
In a declaration on the announcement day after her new role was confirmed, she said: "I know this is a significant undertaking but I approach it with a sense of peace and faith in divine guidance to support me as has consistently occurred."
Addressing media at the historic church, she noted that "during a period that craves certainty and tribalism, Anglicanism provides a more subtle approach but more resilient."
Talking about the "horrific violence" of Thursday's attack on a Jewish house of worship in the northern city, she said "we observe prejudice that emerges through divisions across our communities."
She continued: "The religious community have a duty to be a group who stand with the Jewish community against prejudice against Jews in every manifestation. Hatred and racism of all types cannot be permitted to divide our society."
Married with two children, she spent over 35 years in the National Health Service, achieving the position of the most junior person to serve as chief nurse for the country in 1999.
Although she was volunteering in the religious community at the time, it was just a few years later that she chose to enter a clergy member and was promptly assigned helping make reforms in the way the institution addressed misconduct.
In 2012 she became financial administrator at Salisbury Cathedral before assuming the role of diocesan leader in the regional church administration in 2015.
As London's religious leader she was regarded as someone who used her experience as an health service manager to help update the diocese.
"I am often asked what it has been like to have had two careers, initially in the health service and currently in the Church.
"I like to consider that I have consistently maintained one vocation: to pursue Christian faith, to understand his teachings and to make him known, continually striving to demonstrate empathy in the assistance to people, whether as a nurse, a priest, or a bishop."
Perhaps the pressing issue in her agenda is still to chart a better path towards dealing with abuse and approaching with greater empathy those affected by it.
There has also been a reduction in religious participation, though the capital has to a degree bucked that trend.
A particular subject she has been most outspoken about is assisted dying - she is a vociferous opponent, as was her predecessor.
When the law was approved in the House of Commons, she described it as "unworkable and unsafe and poses a risk to the most at-risk individuals in our society."
One of her roles as London's religious leader was to lead a body trying to guide the Church's decision on whether to bless same-sex marriages.
She characterized the determination to finally allow priests to sanction gay relationships in last year as "an optimistic development for the Church."
Rowan Williams, described her new role as requiring a "awareness of current affairs and a understanding of scripture."
Dr Williams told journalists "the pressure of having an position on all matters is significantly demanding."
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